Chrome can access Dynamics CRM 2106 on Prem but IE can't?

I have a problem, something changed last week and no one in our office can connect to Dynamics CRM 2016 on Prem using IE (any version) but Chrome is working fine.

IE is locked in a loop of asking for credentials and then failing after three or four attempts.

Any idea where I might start looking - This is not limited to one PC/OS or version of IE.

Thanks,

Carl.